mouse CLSTN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Clstn1.
shADV-255700
Ad-m-CLSTN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Clstn1 (calsyntenin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810034E21Rik; Cst-1; Cstn1
Description (Vector)
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Gene ID
65945
Gene Name (Vector)
calsyntenin 1
Gene Symbol
Clstn1
ORF Size (aa)
2910
ORF Size (bp)
2910 bp
RefSeq ID
NM_023051
RefSeq Synonyms
NM_023051, NM_001290989, BC053843,
Species
mouse
UniGene ID
Mm.38993
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.