mouse CHMP1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Chmp1a.
shADV-255409
Ad-m-CHMP1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Chmp1a (charged multivesicular body protein 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2900018H07Rik; Pcoln3
Description (Vector)
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
Gene ID
234852
Gene Name (Vector)
charged multivesicular body protein 1A
Gene Symbol
Chmp1a
ORF Size (aa)
591
RefSeq ID
NM_145606
RefSeq Synonyms
NM_145606, BC036152, BC036138, BC023807, BC010524,
Species
mouse
UniGene ID
Mm.41596
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.