mouse CDK4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cdk4.
shADV-255163
Ad-m-CDK4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cdk4 (cyclin-dependent kinase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Crk3
Description (Vector)
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Gene ID
12567
Gene Name (Vector)
cyclin-dependent kinase 4
Gene Symbol
Cdk4
ORF Size (aa)
912
RefSeq ID
NM_009870
RefSeq Synonyms
NM_009870, BC052694, BC046336,
Species
mouse
UniGene ID
Mm.6839
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.