mouse CD46 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cd46.
shADV-255015
Ad-m-CD46-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cd46 (CD46 antigen, complement regulatory protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mcp
Description (Vector)
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Gene ID
17221
Gene Name (Vector)
CD46 antigen, complement regulatory protein
Gene Symbol
Cd46
ORF Size (aa)
1098
ORF Size (bp)
1098 bp
RefSeq ID
NM_010778
RefSeq Synonyms
NM_010778, BC150660,
Species
mouse
UniGene ID
Mm.12884
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.