mouse CACNA1C shRNA silencing Adenovirus

Name 
Ad-m-CACNA1C-shRNA
Cat No 
shADV-254358
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Cacna1c.

shADV-254358
Ad-m-CACNA1C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC
Description (Vector)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
Gene ID
12288
Gene Name (Vector)
calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol
Cacna1c
ORF Size (aa)
6420
ORF Size (bp)
6420 bp
RefSeq ID
NM_009781
RefSeq Synonyms
NM_009781, NM_001290335, NM_001256002, NM_001256001, NM_001256000, NM_001255999, NM_001255998, NM_001255997, NM_001159535, NM_001159534, NM_001159533, BC145105, BC145104, BC138031,
Species
mouse
UniGene ID
Mm.436656

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.