mouse BRCA2 shRNA silencing Adenovirus

Name 
Ad-m-BRCA2-shRNA
Cat No 
shADV-254070
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Brca2.

shADV-254070
Ad-m-BRCA2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Brca2 (breast cancer 2, early onset). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Fancd1; RAB163
Description (Vector)
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.
Gene ID
12190
Gene Name (Vector)
breast cancer 2, early onset
Gene Symbol
Brca2
ORF Size (aa)
9990
ORF Size (bp)
9990 bp
RefSeq ID
NM_009765
RefSeq Synonyms
NM_009765, NM_001081001, BC172649,
Species
mouse
UniGene ID
Mm.236256

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.