mouse BLM shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Blm.
shADV-253995
Ad-m-BLM-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Blm (Bloom syndrome, RecQ helicase-like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Bloom syndrome homolog; Bloom syndrome protein homolog; Bloom syndrome, RecQ helicase-like; mBLM; recQ helicase homolog
Description (eCommerce)
Bloom syndrome protein (BLM) is a RecQ DNA-helicase that plays a role in DNA replication and repair. Mutations and inactivation of BLM result in human syndromes characterized by dwarfism, infertility, erythema, learning disabilities, immune deficiency and predisposition to cancer. BLM has been shown to associate with the BRCA1-associated genome surveillance complex (BASC) which contains BRCA1, MSH2, MSH6, MLH1, ATM, PMS2 and the RAD50-MRE11-NBS1 protein complex.
Description (Vector)
Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
Gene ID
12144
Gene Name (eCommerce)
Bloom syndrome, RecQ like helicase
Gene Name (Vector)
Bloom syndrome, RecQ helicase-like
Gene Symbol
Blm
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
4251
ORF Size (bp)
4251 bp
Protein Name (eCommerce)
Bloom syndrome protein homolog
RefSeq ID
NM_007550
RefSeq Synonyms
NM_007550, NM_001042527, BC157095,
Research Areas
Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Helicase Activity,Homologous Recombination,Immunology,Prostate Cancer,Replication,Telomeric Maintenance,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology
Species
mouse
Target Sentence
Bloom syndrome protein (BLM) is a RecQ DNA-helicase that plays a role in DNA replication and repair. Mutations and inactivation of BLM result in human syndromes characterized by dwarfism, infertility, erythema, learning disabilities, immune deficiency and predisposition to cancer. BLM has been shown to associate with the BRCA1-associated genome surveillance complex (BASC) which contains BRCA1, MSH2, MSH6, MLH1, ATM, PMS2 and the RAD50-MRE11-NBS1 protein complex.
UniGene ID
Mm.12932
UniProt ID (eCommerce)
O88700
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.