mouse ARG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Arg1.
shADV-252923
Ad-m-ARG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Arg1 (arginase, liver). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI; AI256583; Arg-1; arginase 1, liver; arginase I; arginase-1; liver-type arginase; PGIF; type I arginase
Description (eCommerce)
Arginase1 is a key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P05089].
Gene ID
11846
Gene Name (eCommerce)
arginase, liver
Gene Name (Vector)
arginase, liver
Gene Symbol
Arg1
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
972
ORF Size (bp)
972 bp
Protein Name (eCommerce)
Arginase-1
RefSeq ID
NM_007482
RefSeq Synonyms
NM_007482, BC050005, BC013341,
Research Areas
Cardiovascular,Immune Cells and Tumor Markers,Immuno-Oncology,Interleukin Signaling,Metabolism/Metabolic Process,Neurobiology,RNA Processing,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,immuno_oncology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
mouse
Target Sentence
Arginase1 is a key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P05089].
UniGene ID
Mm.154144
UniProt ID (eCommerce)
Q61176
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.