mouse APC shRNA silencing Adenovirus

Name 
Ad-m-APC-shRNA
Cat No 
shADV-252807
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Apc.

shADV-252807
Ad-m-APC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Apc (adenomatosis polyposis coli). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
65
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI047805; AU020952; AW124434; CC1; mAPC; Min
Description (Vector)
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Gene ID
11789
Gene Name (Vector)
adenomatosis polyposis coli
Gene Symbol
Apc
ORF Size (aa)
8529
ORF Size (bp)
8529 bp
RefSeq ID
NM_007462
RefSeq Synonyms
NM_007462, BC141141,
Species
mouse
UniGene ID
Mm.384171

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.