mouse AIRE shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Aire.
shADV-252378
Ad-m-AIRE-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Gene ID
11634
Gene Name (Vector)
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Gene Symbol
Aire
ORF Size (aa)
954
RefSeq ID
NM_009646
RefSeq Synonyms
NM_009646, NM_001271559, NM_001271558, NM_001271557, NM_001271556, NM_001271555, NM_001271554, NM_001271553, NM_001271552, NM_001271551, NM_001271550, NM_001271549, BC103518, BC103511, BC103510,
Species
mouse
UniGene ID
Mm.35300
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.