mouse AGT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Agt.
shADV-252250
Ad-m-AGT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI265500; AngI; AngII; Aogen; Serpina8
Description (Vector)
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2|Function: Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone|Function: Angiotensin-3 stimulates aldosterone release|Function: Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).
Gene ID
11606
Gene Name (Vector)
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Symbol
Agt
ORF Size (aa)
1434
ORF Size (bp)
1434 bp
RefSeq ID
NM_007428
RefSeq Synonyms
NM_007428, BC156904, BC156111, BC054387, BC028877, BC019496,
Species
mouse
UniGene ID
Mm.301626
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.