mouse ADAM10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Adam10.
shADV-252035
Ad-m-ADAM10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Adam10 (a disintegrin and metallopeptidase domain 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1700031C13Rik; kuz; kuzbanian; MADM
Description (Vector)
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Gene ID
11487
Gene Name (Vector)
a disintegrin and metallopeptidase domain 10
Gene Symbol
Adam10
ORF Size (aa)
2250
ORF Size (bp)
2250 bp
RefSeq ID
NM_007399
RefSeq Synonyms
NM_007399, BC168390,
Species
mouse
UniGene ID
Mm.3037
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.