human RPGR shRNA silencing Adenovirus

Name 
Ad-h-RPGR-shRNA
Cat No 
shADV-234103
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RPGR.

shADV-234103
Ad-h-RPGR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RPGR (retinitis pigmentosa GTPase regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COD1; CORDX1; CRD; orf15; PCDX; retinitis pigmentosa 15; retinitis pigmentosa 3 GTPase regulator; RP15; RP3; X-linked retinitis pigmentosa GTPase regulator; XLRP3
Description (eCommerce)
X-linked retinitis pigmentosa GTPase regulator (RPGR) could be a guanine-nucleotide releasing factor. It plays a role in ciliogenesis and probably regulates cilia formation by regulating actin stress filaments and cell contractility. RPGR plays an important role in photoreceptor integrity. It may also play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92834].
Description (Vector)
RPGR encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
Gene ID
6103
Gene Name (eCommerce)
retinitis pigmentosa GTPase regulator
Gene Name (Vector)
retinitis pigmentosa GTPase regulator
Gene Symbol
RPGR
HGNC ID
HGNC:10295
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
Protein Name (eCommerce)
X-linked retinitis pigmentosa GTPase regulator
RefSeq ID
NM_000328
RefSeq Synonyms
NM_001034853, NM_000328, BC031624,
Research Areas
Cytoskeleton,Golgi Apparatus,Neurobiology
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
X-linked retinitis pigmentosa GTPase regulator (RPGR) could be a guanine-nucleotide releasing factor. It plays a role in ciliogenesis and probably regulates cilia formation by regulating actin stress filaments and cell contractility. RPGR plays an important role in photoreceptor integrity. It may also play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92834].
UniProt ID (eCommerce)
Q92834

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.