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human ARAP3 shRNA silencing Adenovirus

Name 
Ad-h-ARAP3-shRNA
Cat No 
shADV-233516
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ARAP3.

shADV-233516
Ad-h-ARAP3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Arf and Rho GAP adapter protein 3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; centaurin-delta-3; CENTD3; Cnt-d3; DRAG1; phosphoinositide binding protein; PtdIns(3,4,5)P3-binding protein
Description (eCommerce)
ARAP3 is a phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. It is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. It can also be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP3 acts on ARF6, RAC1, RHOA and CDC42. ARAP3 plays a role in the internalization of anthrax toxin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WWN8].
Description (Vector)
ARAP3 encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined.
Gene ID
64411
Gene Name (eCommerce)
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Gene Name (Vector)
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Gene Symbol
ARAP3
HGNC ID
HGNC:24097
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
964
ORF Size (bp)
964 bp
Protein Name (eCommerce)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
RefSeq ID
NM_022481
RefSeq Synonyms
NM_022481, BC009968,
Research Areas
Cytoskeleton,Rho Signaling,Signal Transduction,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
ARAP3 is a phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. It is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. It can also be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP3 acts on ARF6, RAC1, RHOA and CDC42. ARAP3 plays a role in the internalization of anthrax toxin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WWN8].
UniProt ID (eCommerce)
Q8WWN8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.