human PPARA shRNA silencing Adenovirus

Name
Ad-h-PPARA-shRNA

Cat No
shADV-232982

Availability
5-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human PPARA.

shADV-232982

Ad-h-PPARA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PPARA (peroxisome proliferator activated receptor alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

hPPAR; NR1C1; PPAR; PPARalpha

Description (Vector)

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

Gene ID

5465

Gene Name (Vector)

peroxisome proliferator activated receptor alpha

Gene Symbol

PPARA

HGNC ID

HGNC:9232

ORF Size (aa)

1407

ORF Size (bp)

1407 bp

RefSeq ID

NM_005036

RefSeq Synonyms

NM_005036, NM_001001928, BC000052,

Species

human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.