human CLDN14 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CLDN14.
shADV-231211
Ad-h-CLDN14-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CLDN14 (claudin 14). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DFNB29
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.
Gene ID
23562
Gene Name (Vector)
claudin 14
Gene Symbol
CLDN14
HGNC ID
HGNC:2035
ORF Size (aa)
720
RefSeq ID
NM_012130
RefSeq Synonyms
NM_144492, NM_012130, NM_001146079, NM_001146078, NM_001146077, BC012126,
Species
human
UniGene ID
Hs.660278
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.