human C4B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human C4B.
shADV-230319
Ad-h-C4B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human C4B (complement C4B (Chido blood group)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2; C4F; CH; CO4; CPAMD3
Description (Vector)
C4B encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. C4B localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Gene ID
721
Gene Name (Vector)
complement C4B (Chido blood group)
Gene Symbol
C4B
HGNC ID
HGNC:1324
ORF Size (aa)
5235
ORF Size (bp)
5235 bp
RefSeq ID
NM_001002029
RefSeq Synonyms
NM_001002029, BC172377,
Species
human
UniGene ID
Hs.
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.