mouse C4B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse C4b.
shAAV-254282
AAV-m-C4B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse C4b (complement component 4B (Chido blood group)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C4; Ss
Description (Vector)
C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway|Function: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Gene ID
12268
Gene Name (Vector)
complement component 4B (Chido blood group)
Gene Symbol
C4b
ORF Size (aa)
5217
ORF Size (bp)
5217 bp
RefSeq ID
NM_009780
RefSeq Synonyms
NM_009780, BC158005, BC150743, BC067409, BC067394,
Species
mouse
UniGene ID
Mm.439678
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.