human SNCA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SNCA.
shADV-230206
Ad-h-SNCA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SNCA (synuclein alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NACP; PARK1; PARK4; PD1
Description (Vector)
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Gene ID
6622
Gene Name (Vector)
synuclein alpha
Gene Symbol
SNCA
HGNC ID
HGNC:11138
ORF Size (aa)
423
ORF Size (bp)
423 bp
RefSeq ID
NM_000345
RefSeq Synonyms
NM_007308, NM_001146055, NM_001146054, NM_000345, BC108275, BC013293,
Species
human
UniGene ID
Hs.21374
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.