human PCSK7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCSK7.
shADV-229915
Ad-h-PCSK7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCSK7 (proprotein convertase subtilisin/kexin type 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LPC; PC7; PC8; SPC7
Description (Vector)
PCSK7 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
Gene ID
9159
Gene Name (Vector)
proprotein convertase subtilisin/kexin type 7
Gene Symbol
PCSK7
HGNC ID
HGNC:8748
ORF Size (aa)
2358
ORF Size (bp)
2358 bp
RefSeq ID
NM_004716
RefSeq Synonyms
NM_004716, BC010696, BC006357,
Species
human
UniGene ID
Hs.648612
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.