human HBA1 shRNA silencing Adenovirus

Name
Ad-h-HBA1-shRNA

Cat No
shADV-229634

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human HBA1.

shADV-229634

Ad-h-HBA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HBA1 (hemoglobin subunit alpha 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HBA-T3; HBH

Description (Vector)

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Gene ID

3039

Gene Name (Vector)

hemoglobin subunit alpha 1

Gene Symbol

HBA1

HGNC ID

HGNC:4823

ORF Size (aa)

429

RefSeq ID

NM_000558

RefSeq Synonyms

NM_000558, BC101848, BC101846, BC050661, BC032122, BC008572, BC005931,

Species

human

UniGene ID

Hs.449630

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.