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human ZC3HC1 shRNA silencing Adenovirus

Name 
Ad-h-ZC3HC1-shRNA
Cat No 
shADV-228109
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ZC3HC1.

shADV-228109
Ad-h-ZC3HC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ZC3HC1 (zinc finger C3HC-type containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hematopoietic stem/progenitor cell protein 216; hNIPA; HSPC216; NIPA; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; Zinc finger C3HC-type protein 1
Description (eCommerce)
Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
Gene ID
51530
Gene Name (eCommerce)
zinc finger C3HC-type containing 1
Gene Name (Vector)
zinc finger C3HC-type containing 1
Gene Symbol
ZC3HC1
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
Protein Name (eCommerce)
Nuclear-interacting partner of ALK
RefSeq ID
NM_016478
RefSeq Synonyms
NM_016478, NM_001282191, NM_001282190, BC028917, BC011551,
Research Areas
Cell Cycle,Cell Division,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
UniGene ID
Hs.194157
UniProt ID (eCommerce)
Q86WB0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.