human WNT1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human WNT1.
shADV-227810
Ad-h-WNT1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human WNT1 (Wnt family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BMND16; INT1; OI15
Description (Vector)
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
Gene ID
7471
Gene Name (Vector)
Wnt family member 1
Gene Symbol
WNT1
HGNC ID
HGNC:12774
ORF Size (aa)
1113
RefSeq ID
NM_005430
RefSeq Synonyms
NM_005430, BC074799, BC074798,
Species
human
UniGene ID
Hs.248164
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.