human VTCN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human VTCN1.
shADV-227575
Ad-h-VTCN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human VTCN1 (V-set domain containing T cell activation inhibitor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7S1; B7X; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; VCTN1; V-set domain-containing T-cell activation inhibitor 1
Description (eCommerce)
B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P10914].
Description (Vector)
VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
79679
Gene Name (eCommerce)
V-set domain containing T cell activation inhibitor 1
Gene Name (Vector)
V-set domain containing T cell activation inhibitor 1
Gene Symbol
VTCN1
HGNC ID
HGNC:28873
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
564
Protein Name (eCommerce)
V-set domain-containing T-cell activation inhibitor 1
RefSeq ID
NM_024626
RefSeq Synonyms
NM_024626, NM_001253850, NM_001253849, BC074729, BC065717,
Research Areas
Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P10914].
UniGene ID
Hs.546434
UniProt ID (eCommerce)
Q7Z7D3
Recently Viewed Products
Ad-h-TMEM5-shRNA
Cat No: shADV-225911
Ad-m-VTCN1-shRNA
Cat No: shADV-276105
Ad-h-SLC25A39-shRNA
Cat No: shADV-229631
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.