human VEGFA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human VEGFA.
shADV-227457
Ad-h-VEGFA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human VEGFA (vascular endothelial growth factor A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MVCD1; VEGF; VPF
Description (Vector)
VEGFA is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
Gene ID
7422
Gene Name (Vector)
vascular endothelial growth factor A
Gene Symbol
VEGFA
HGNC ID
HGNC:12680
ORF Size (aa)
1188
RefSeq ID
NM_003376
RefSeq Synonyms
NM_003376, NM_001317010, NM_001287044, NM_001204385, NM_001204384, NM_001171630, NM_001171629, NM_001171628, NM_001171627, NM_001171626, NM_001171625, NM_001171624, NM_001171623, NM_001171622, NM_001033756, NM_001025370, NM_001025369, NM_001025368, NM_001025367, NM_001025366, BC172307, BC065522,
Species
human
UniGene ID
Hs.73793
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.