human USP48 shRNA silencing Adenovirus

Name 
Ad-h-USP48-shRNA
Cat No 
shADV-227336
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human USP48.

shADV-227336
Ad-h-USP48-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human USP48 (ubiquitin specific peptidase 48). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
deubiquitinating enzyme 48; RAP1GA1; ubiquitin carboxyl-terminal hydrolase 48; ubiquitin specific protease 31; ubiquitin thioesterase 48; ubiquitin thiolesterase 48; Ubiquitin-specific peptidase 48; Ubiquitin-specific protease 48; ubiquitin-specific-processing protease 48; USP31
Description (eCommerce)
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific peptidase 48 (USP48) is a member of the C19 peptidase family involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. USP48 is involved in the activation of NF-kappa B via its interaction with RELA and TRAF2.
Description (Vector)
USP48 encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
84196
Gene Name (eCommerce)
ubiquitin specific peptidase 48
Gene Name (Vector)
ubiquitin specific peptidase 48
Gene Symbol
USP48
HGNC ID
HGNC:18533
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3108
ORF Size (bp)
3108 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase 48
RefSeq ID
NM_032236
RefSeq Synonyms
NM_032236, NM_001330394, NM_001032730, BC143354, BC143349, BC143343, BC104896, BC013567, BC011576,
Research Areas
Mitochondrion,Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific peptidase 48 (USP48) is a member of the C19 peptidase family involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. USP48 is involved in the activation of NF-kappa B via its interaction with RELA and TRAF2.
UniGene ID
Hs.467524
UniProt ID (eCommerce)
Q86UV5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.