human USP24 shRNA silencing Adenovirus

Name 
Ad-h-USP24-shRNA
Cat No 
shADV-227298
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human USP24.

shADV-227298
Ad-h-USP24-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human USP24 (ubiquitin specific peptidase 24). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
deubiquitinating enzyme 24; ubiquitin carboxyl-terminal hydrolase 24; ubiquitin specific protease 24; ubiquitin thioesterase 24; ubiquitin thiolesterase 24; ubiquitin-specific processing protease 24; Ubiquitin-specific-processing protease 24
Description (eCommerce)
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 24 (USP24) is a member of this family.
Description (Vector)
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied by OMIM, Mar 2008)
Gene ID
23358
Gene Name (eCommerce)
ubiquitin specific peptidase 24
Gene Name (Vector)
ubiquitin specific peptidase 24
Gene Symbol
USP24
HGNC ID
HGNC:12623
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7383
ORF Size (bp)
7383 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase 24
RefSeq ID
NM_015306
RefSeq Synonyms
NM_015306, BC160138,
Research Areas
Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 24 (USP24) is a member of this family.
UniGene ID
Hs.477009
UniProt ID (eCommerce)
Q9UPU5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.