human UGDH shRNA silencing Adenovirus

Name 
Ad-h-UGDH-shRNA
Cat No 
shADV-227136
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human UGDH.

shADV-227136
Ad-h-UGDH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human UGDH (UDP-glucose 6-dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GDH; UDPGDH; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; UGD; uridine diphospho-glucose dehydrogenase
Description (eCommerce)
UDP-glucose 6-dehydrogenase (UGDH) is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60701].
Description (Vector)
UGDH converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Gene ID
7358
Gene Name (eCommerce)
UDP-glucose 6-dehydrogenase
Gene Name (Vector)
UDP-glucose 6-dehydrogenase
Gene Symbol
UGDH
HGNC ID
HGNC:12525
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
Protein Name (eCommerce)
UDP-glucose 6-dehydrogenase
RefSeq ID
NM_003359
RefSeq Synonyms
NM_003359, NM_001184701, NM_001184700, BC022781,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
UDP-glucose 6-dehydrogenase (UGDH) is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60701].
UniGene ID
Hs.572518
UniProt ID (eCommerce)
O60701

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.