human UBE2L3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human UBE2L3.
shADV-227022
Ad-h-UBE2L3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human UBE2L3 (ubiquitin conjugating enzyme E2 L3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E2 ubiquitin-conjugating enzyme L3; E2-F1; L-UBC; UBCH7; UbcM4; ubiquitin carrier protein L3; ubiquitin conjugating enzyme E2L 3; ubiquitin-conjugating enzyme E2 L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase L3
Description (eCommerce)
Ubiquitin conjugating enzyme H7 (UBCH7) is an E2 enzyme of the three step ubiquitination pathway. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ubiquitination provides an important post-translational means to regulate protein abundance and activity. UBCH7 has been shown to be involved in the ubiquitination of p53.
Description (Vector)
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.
Gene ID
7332
Gene Name (eCommerce)
ubiquitin conjugating enzyme E2 L3
Gene Name (Vector)
ubiquitin conjugating enzyme E2 L3
Gene Symbol
UBE2L3
HGNC ID
HGNC:12488
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
465
Protein Name (eCommerce)
Ubiquitin-conjugating enzyme E2 L3
RefSeq ID
NM_003347
RefSeq Synonyms
NM_003347, NM_001256356, NM_001256355, BC053368,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Immunology,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Signal Transduction,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,cell_cycle,immunology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
Ubiquitin conjugating enzyme H7 (UBCH7) is an E2 enzyme of the three step ubiquitination pathway. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ubiquitination provides an important post-translational means to regulate protein abundance and activity. UBCH7 has been shown to be involved in the ubiquitination of p53.
UniGene ID
Hs.715088
UniProt ID (eCommerce)
P68036
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.