mouse UBE2L3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ube2l3.
shAAV-275483
AAV-m-UBE2L3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ube2l3 (ubiquitin-conjugating enzyme E2L 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C79827; Ubce7; UbcM4
Description (Vector)
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Gene ID
22195
Gene Name (Vector)
ubiquitin-conjugating enzyme E2L 3
Gene Symbol
Ube2l3
ORF Size (aa)
465
RefSeq ID
NM_009456
RefSeq Synonyms
NM_009456, BC106149, BC093503,
Species
mouse
UniGene ID
Mm.3074
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.