human TSC22D1 shRNA silencing Adenovirus

Name 
Ad-h-TSC22D1-shRNA
Cat No 
shADV-226579
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TSC22D1.

shADV-226579
Ad-h-TSC22D1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TSC22D1 (TSC22 domain family member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cerebral protein 2; Ptg-2; regulatory protein TSC-22; TGFB1I4; TGFbeta-stimulated clone 22; TGFB-stimulated clone 22 homolog; transcriptional regulator TSC-22; transforming growth factor beta-1-induced transcript 4 protein; transforming growth factor beta-stimulated protein TSC-22; TSC22; TSC22 domain family protein 1
Description (eCommerce)
TSC22 domain family protein 1 (TSC22D1) is a member of the TSC22 domain family of leucine zipper transcription factors. TSC22D1 is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. TSC22D1 may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy [taken from NCBI Entrez Gene (Gene ID: 8848)].
Description (Vector)
TSC22D1 encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
8848
Gene Name (eCommerce)
TSC22 domain family member 1
Gene Name (Vector)
TSC22 domain family member 1
Gene Symbol
TSC22D1
HGNC ID
HGNC:16826
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3222
ORF Size (bp)
3222 bp
Protein Name (eCommerce)
TSC22 domain family protein 1
RefSeq ID
NM_006022
RefSeq Synonyms
NM_183422, NM_006022, NM_001243799, NM_001243798, NM_001243797, BC136482, BC136475, BC000456,
Research Areas
Apoptosis,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
TSC22 domain family protein 1 (TSC22D1) is a member of the TSC22 domain family of leucine zipper transcription factors. TSC22D1 is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. TSC22D1 may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy [taken from NCBI Entrez Gene (Gene ID: 8848)].
UniGene ID
Hs.507916
UniProt ID (eCommerce)
Q15714

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.