human TRIP13 shRNA silencing Adenovirus

Name 
Ad-h-TRIP13-shRNA
Cat No 
shADV-226499
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TRIP13.

shADV-226499
Ad-h-TRIP13-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TRIP13 (thyroid hormone receptor interactor 13). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
16E1BP; 16E1-BP; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; human papillomavirus type 16 E1 protein-binding protein; MVA3; pachytene checkpoint protein 2 homolog; SH3TC1/TRIP13 fusion; Thyroid hormone receptor interactor 13; thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
Description (eCommerce)
TRIP13 (thyroid hormone receptor interactor 13) plays a key role in chromosome recombination and chromosome structure development during meiosis. TRIP13 is required at early steps in meiotic recombination that leads to non-crossovers pathways. It is also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15645].
Description (Vector)
TRIP13 encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. TRIP13 is one of several that may play a role in early-stage non-small cell lung cancer.
Gene ID
9319
Gene Name (eCommerce)
thyroid hormone receptor interactor 13
Gene Name (Vector)
thyroid hormone receptor interactor 13
Gene Symbol
TRIP13
HGNC ID
HGNC:12307
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1299
ORF Size (bp)
1299 bp
Protein Name (eCommerce)
Pachytene checkpoint protein 2 homolog
RefSeq ID
NM_004237
RefSeq Synonyms
NM_004237, NM_001166260, BC019294, BC000404,
Research Areas
Cell Cycle,DNA Damage/Repair,Immunology,Meiosis,Spermatogenesis,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
TRIP13 (thyroid hormone receptor interactor 13) plays a key role in chromosome recombination and chromosome structure development during meiosis. TRIP13 is required at early steps in meiotic recombination that leads to non-crossovers pathways. It is also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15645].
UniGene ID
Hs.436187
UniProt ID (eCommerce)
Q15645

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.