human TRAP1 shRNA silencing Adenovirus

Name 
Ad-h-TRAP1-shRNA
Cat No 
shADV-226346
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TRAP1.

shADV-226346
Ad-h-TRAP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TRAP1 (TNF receptor associated protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75; HSP90L; testicular tissue protein Li 209; TNFR-associated protein 1; TRAP-1; tumor necrosis factor type 1 receptor-associated protein
Description (eCommerce)
TRAP1/HSP75 encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses [taken from NCBI Entrez Gene (Gene ID: 10131)].
Description (Vector)
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 (PubMed 16269234)).(supplied by OMIM, Aug 2008)
Gene ID
10131
Gene Name (eCommerce)
TNF receptor associated protein 1
Gene Name (Vector)
TNF receptor associated protein 1
Gene Symbol
TRAP1
HGNC ID
HGNC:16264
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2115
ORF Size (bp)
2115 bp
Protein Name (eCommerce)
Heat shock protein 75 kDa, mitochondrial
RefSeq ID
NM_016292
RefSeq Synonyms
NM_016292, NM_001272049, BC023585, BC018950,
Research Areas
Cancer,Mitochondrion,Protein Folding,Signal Transduction,TGF-beta Signaling,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
TRAP1/HSP75 encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses [taken from NCBI Entrez Gene (Gene ID: 10131)].
UniGene ID
Hs.30345
UniProt ID (eCommerce)
Q12931

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.