human TRAF3IP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TRAF3IP2.
shADV-226328
Ad-h-TRAF3IP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TRAF3IP2 (TRAF3 interacting protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; DKFZp586G0522; MGC3581;
Description (Vector)
TRAF3IP2 encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. TRAF3IP2 product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Gene ID
10758
Gene Name (Vector)
TRAF3 interacting protein 2
Gene Symbol
TRAF3IP2
HGNC ID
HGNC:1343
ORF Size (aa)
1698
ORF Size (bp)
1698 bp
RefSeq ID
NM_001164282
RefSeq Synonyms
NM_147686, NM_147200, NM_001164283, NM_001164282, NM_001164281, BC002823,
Species
human
UniGene ID
Hs.654708
Related Citations
- Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-¿B/iNOS/NO-dependent cardiomyocyte contractile depression and death. T Yoshida, etc, (2020), Cellular Signalling
- The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1ß and IL-18 secretion. S Sukhanov, etc, (2020), Cellular Signalling
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.