human TPSAB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TPSAB1.
shADV-226297
Ad-h-TPSAB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TPSAB1 (tryptase alpha/beta 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TPS1; TPS2; TPSB1
Description (Vector)
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Gene ID
7177
Gene Name (Vector)
tryptase alpha/beta 1
Gene Symbol
TPSAB1
HGNC ID
HGNC:12019
ORF Size (aa)
828
RefSeq ID
NM_003294
RefSeq Synonyms
NM_003294, BC074975, BC028059,
Species
human
UniGene ID
Hs.405479
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.