human TNFSF4 shRNA silencing Adenovirus

Name 
Ad-h-TNFSF4-shRNA
Cat No 
shADV-226112
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNFSF4.

shADV-226112
Ad-h-TNFSF4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFSF4 (tumor necrosis factor superfamily member 4). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD252; CD134 ligand; CD134L; CD252; glycoprotein Gp34; GP34; OX40 antigen ligand; OX40 ligand; OX40L; OX-40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor ligand 2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1
Description (eCommerce)
OX40L/TNFSF4 is a cytokine of the tumor necrosis factor (TNF) ligand family. OX40L/TNFSF4 functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. [taken from NCBI Entrez Gene (Gene ID: 7292)].
Description (Vector)
TNFSF4 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Gene ID
7292
Gene Name (eCommerce)
TNF superfamily member 4
Gene Name (Vector)
tumor necrosis factor superfamily member 4
Gene Symbol
TNFSF4
HGNC ID
HGNC:11934
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
402
Protein Name (eCommerce)
Tumor necrosis factor ligand superfamily member 4
RefSeq ID
NM_003326
RefSeq Synonyms
NM_003326, NM_001297562, BC041663,
Research Areas
Cancer,Host-Virus Interactions,Immunology,Response to Virus,Signal Transduction,TSLP Signaling
Research Areas (Faceted)
cancer,signal_transduction,infectious_disease,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
OX40L/TNFSF4 is a cytokine of the tumor necrosis factor (TNF) ligand family. OX40L/TNFSF4 functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. [taken from NCBI Entrez Gene (Gene ID: 7292)].
UniGene ID
Hs.181097
UniProt ID (eCommerce)
P23510

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.