human TNFRSF8 shRNA silencing Adenovirus

Name 
Ad-h-TNFRSF8-shRNA
Cat No 
shADV-226094
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNFRSF8.

shADV-226094
Ad-h-TNFRSF8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFRSF8 (TNF receptor superfamily member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD30; CD30; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; lymphocyte activation antigen CD30; TNFRSF8; tumor necrosis factor receptor superfamily member 8
Description (eCommerce)
CD30 is a member of the TNF-receptor superfamily, expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity [provided by RefSeq, Jul 2008] [taken from NCBI Entrez Gene (Gene ID: 943)].
Description (Vector)
TNFRSF8 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gene ID
943
Gene Name (eCommerce)
TNF receptor superfamily member 8
Gene Name (Vector)
TNF receptor superfamily member 8
Gene Symbol
TNFRSF8
HGNC ID
HGNC:11923
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1452
ORF Size (bp)
1452 bp
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 8
RefSeq ID
NM_001243
RefSeq Synonyms
NM_152942, NM_001281430, NM_001243, BC136400,
Research Areas
Apoptosis,Cancer,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology
Species
human
Target Sentence
CD30 is a member of the TNF-receptor superfamily, expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity [provided by RefSeq, Jul 2008] [taken from NCBI Entrez Gene (Gene ID: 943)].
UniGene ID
Hs.1314
UniProt ID (eCommerce)
P28908

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.