human TMEM127 shRNA silencing Adenovirus

Name 
Ad-h-TMEM127-shRNA
Cat No 
shADV-225728
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TMEM127.

shADV-225728
Ad-h-TMEM127-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TMEM127 (transmembrane protein 127). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
transmembrane protein 127
Description (eCommerce)
Transmembrane protein 127 (TMEM127) controls cell proliferation by acting as a negative regulator of the mTOR signaling pathway mediated by mTORC1. TMEM127 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O75204].
Description (Vector)
TMEM127 encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified.
Gene ID
55654
Gene Name (eCommerce)
transmembrane protein 127
Gene Name (Vector)
transmembrane protein 127
Gene Symbol
TMEM127
HGNC ID
HGNC:26038
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
717
Protein Name (eCommerce)
Transmembrane protein 127
RefSeq ID
NM_017849
RefSeq Synonyms
NM_017849, NM_001193304, BC039892, BC028575,
Research Areas
Cancer,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,signal_transduction
Species
human
Target Sentence
Transmembrane protein 127 (TMEM127) controls cell proliferation by acting as a negative regulator of the mTOR signaling pathway mediated by mTORC1. TMEM127 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O75204].
UniGene ID
Hs.355708
UniProt ID (eCommerce)
O75204

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.