human THRB shRNA silencing Adenovirus

Name
Ad-h-THRB-shRNA

Cat No
shADV-225470

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human THRB.

shADV-225470

Ad-h-THRB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human THRB (thyroid hormone receptor beta). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2

Description (Vector)

THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Gene ID

7068

Gene Name (Vector)

thyroid hormone receptor beta

Gene Symbol

THRB

HGNC ID

HGNC:11799

ORF Size (aa)

1386

ORF Size (bp)

1386 bp

RefSeq ID

NM_000461

RefSeq Synonyms

NM_001252634, NM_001128177, NM_001128176, NM_000461, BC106930, BC106929,

Species

human

UniGene ID

Hs.187861

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.