human THBD shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human THBD.
shADV-225431
Ad-h-THBD-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human THBD (thrombomodulin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AHUS6; BDCA3; CD antigen CD141; CD141; CD141 antigen; fetomodulin; THPH12; THRM; thrombomodulin; TM
Description (eCommerce)
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07204].
Description (Vector)
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Gene ID
7056
Gene Name (eCommerce)
thrombomodulin
Gene Name (Vector)
thrombomodulin
Gene Symbol
THBD
HGNC ID
HGNC:11784
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1728
ORF Size (bp)
1728 bp
Protein Name (eCommerce)
Thrombomodulin
RefSeq ID
NM_000361
RefSeq Synonyms
NM_000361, BC053357, BC035602,
Research Areas
Cardiovascular,Immunology,Signal Transduction
Research Areas (Faceted)
cardiovascular,immunology,signal_transduction
Species
human
Target Sentence
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07204].
UniGene ID
Hs.2030
UniProt ID (eCommerce)
P07204
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.