human TG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TG.
shADV-225375
Ad-h-TG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TG (thyroglobulin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AITD3; TGN
Description (Vector)
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Gene ID
7038
Gene Name (Vector)
thyroglobulin
Gene Symbol
TG
HGNC ID
HGNC:11764
ORF Size (aa)
8307
ORF Size (bp)
8307 bp
RefSeq ID
NM_003235
RefSeq Synonyms
NM_003235, BC140933,
Species
human
UniGene ID
Hs.654591
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.