human TFG shRNA silencing Adenovirus

Name 
Ad-h-TFG-shRNA
Cat No 
shADV-225366
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TFG.

shADV-225366
Ad-h-TFG-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TFG (TRK-fused gene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HMSNP; protein TFG; SPG57; TF6; TRK-fused gene protein; TRKT3; TRKT3 oncogene
Description (eCommerce)
TRK-fused gene (TFG) has been identified as part of a chromosomal translocation [t(1,3)(q21;q11)] with NTRK1 in thyroid papillary carcinoma. TGF is implicated to play a role in modulating SHP-1 activity and has also been found to interact with TANK and NEMO, two proteins involved in the NF-kappaB signaling pathway.
Description (Vector)
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene.
Gene ID
10342
Gene Name (eCommerce)
TRK-fused gene
Gene Name (Vector)
TRK-fused gene
Gene Symbol
TFG
HGNC ID
HGNC:11758
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1101
Protein Name (eCommerce)
Protein TFG
RefSeq ID
NM_006070
RefSeq Synonyms
NM_006070, NM_001195479, NM_001195478, NM_001007565, BC041600, BC023599, BC009241, BC001483,
Research Areas
Cancer,EGFR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,NF-kB Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
TRK-fused gene (TFG) has been identified as part of a chromosomal translocation [t(1,3)(q21;q11)] with NTRK1 in thyroid papillary carcinoma. TGF is implicated to play a role in modulating SHP-1 activity and has also been found to interact with TANK and NEMO, two proteins involved in the NF-kappaB signaling pathway.
UniGene ID
Hs.518123
UniProt ID (eCommerce)
Q92734

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.