human TFAM shRNA silencing Adenovirus

Name 
Ad-h-TFAM-shRNA
Cat No 
shADV-225343
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TFAM.

shADV-225343
Ad-h-TFAM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TFAM (transcription factor A, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF-6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; Transcription factor 6-like 2; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; transcription factor A, mitochondrial
Description (eCommerce)
Transcription factor A, mitochondrial (TFAM) binds to the mitochondrial light strand promoter and functions in mitochondrial transcriptional regulation. TFAM is required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase and promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. TFMA is required for maintenance of normal levels of mitochondrial DNA and may play a role in organizing and compacting mitochondrial DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q00059].
Description (Vector)
TFAM encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
Gene ID
7019
Gene Name (eCommerce)
transcription factor A, mitochondrial
Gene Name (Vector)
transcription factor A, mitochondrial
Gene Symbol
TFAM
HGNC ID
HGNC:11741
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
741
Protein Name (eCommerce)
Transcription factor A, mitochondrial
RefSeq ID
NM_003201
RefSeq Synonyms
NM_003201, NM_001270782, BC126366,
Research Areas
DNA Replication,Gene Expression,Huntington's Disease,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Transcription Factor/Regulator
Research Areas (Faceted)
metabolism,cell_biology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
Transcription factor A, mitochondrial (TFAM) binds to the mitochondrial light strand promoter and functions in mitochondrial transcriptional regulation. TFAM is required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase and promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. TFMA is required for maintenance of normal levels of mitochondrial DNA and may play a role in organizing and compacting mitochondrial DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q00059].
UniGene ID
Hs.642966
UniProt ID (eCommerce)
Q00059

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.