human TERF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TERF2.
shADV-225307
Ad-h-TERF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TERF2 (telomeric repeat binding factor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
telomeric DNA-binding protein; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Description (eCommerce)
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.
Description (Vector)
TERF2 encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Gene ID
7014
Gene Name (eCommerce)
telomeric repeat binding factor 2
Gene Name (Vector)
telomeric repeat binding factor 2
Gene Symbol
TERF2
HGNC ID
HGNC:11729
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
756
Protein Name (eCommerce)
Telomeric repeat-binding factor 2
RefSeq ID
NM_005652
RefSeq Synonyms
NM_005652, BC024890,
Research Areas
Cell Cycle,Golgi Apparatus,Telomeric Maintenance,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.
UniGene ID
Hs.63335
UniProt ID (eCommerce)
Q15554
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.