human TARDBP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TARDBP.
shADV-224973
Ad-h-TARDBP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TARDBP (TAR DNA binding protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALS10; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TDP-43
Description (eCommerce)
Tar DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing. It is involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP43 may also be involved in microRNA biogenesis, apoptosis and cell division. TDP43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Also, TDP43 stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13148].
Description (Vector)
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Gene ID
23435
Gene Name (eCommerce)
TAR DNA binding protein
Gene Name (Vector)
TAR DNA binding protein
Gene Symbol
TARDBP
HGNC ID
HGNC:11571
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1245
ORF Size (bp)
1245 bp
Protein Name (eCommerce)
TAR DNA-binding protein 43
RefSeq ID
NM_007375
RefSeq Synonyms
NM_007375, BC095435, BC071657,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Host-Virus Interactions,mRNA Binding,mRNA Processing,mRNA Splicing,Neurobiology,Neurodegeneration,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
neurobiology,cell_biology,infectious_disease,genetics,transcription_translation
Species
human
Target Sentence
Tar DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing. It is involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP43 may also be involved in microRNA biogenesis, apoptosis and cell division. TDP43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Also, TDP43 stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13148].
UniGene ID
Hs.635053
UniProt ID (eCommerce)
Q13148
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.