human TADA3L shRNA silencing Adenovirus

Name 
Ad-h-TADA3L-shRNA
Cat No 
shADV-224908
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TADA3.

shADV-224908
Ad-h-TADA3L-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TADA3 (transcriptional adaptor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ADA3; ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; epididymis secretory sperm binding protein; hADA3; NGG1; STAF54; TADA3L; transcriptional adapter 3; Transcriptional adapter 3-like
Description (eCommerce)
The gene TADA3, also known as ADA3 or TADA3L, encodes for the protein transcriptional adapter 3. TADA3/TADA3L is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Transcriptional adapter 3 is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage [taken from NCBI Entrez Gene (Gene ID: 10474)].
Description (Vector)
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
Gene ID
10474
Gene Name (eCommerce)
transcriptional adaptor 3
Gene Name (Vector)
transcriptional adaptor 3
Gene Symbol
TADA3
HGNC ID
HGNC:19422
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Transcriptional adapter 3
RefSeq ID
NM_006354
RefSeq Synonyms
NM_133480, NM_006354, NM_001278270, BC141661, BC013433, BC009240,
Research Areas
Estrogen Signaling,Gene Expression,Histone Modification,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
The gene TADA3, also known as ADA3 or TADA3L, encodes for the protein transcriptional adapter 3. TADA3/TADA3L is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Transcriptional adapter 3 is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage [taken from NCBI Entrez Gene (Gene ID: 10474)].
UniGene ID
Hs.386390
UniProt ID (eCommerce)
O75528

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.