human STK24 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human STK24.
shADV-224584
Ad-h-STK24-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human STK24 (serine/threonine kinase 24). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
epididymis secretory protein Li 95; HEL-S-95; mammalian STE20-like protein kinase 3; MST3; MST-3; MST3B; serine/threonine kinase 24 (STE20 homolog, yeast); serine/threonine-protein kinase 24; STE20; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; STK3
Description (eCommerce)
MST3/STK24 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. In response to apoptotic signals, MST3/STK24 is cleaved by caspase-3 and mediates apoptosis. The biological functions of MST3/STK24 are not well understood.
Description (Vector)
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 (PubMed 10644707)).(supplied by OMIM, Mar 2008)
Gene ID
8428
Gene Name (eCommerce)
serine/threonine kinase 24
Gene Name (Vector)
serine/threonine kinase 24
Gene Symbol
STK24
HGNC ID
HGNC:11403
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase 24
RefSeq ID
NM_003576
RefSeq Synonyms
NM_003576, NM_001286649, NM_001032296, BC065378, BC035578,
Research Areas
Apoptosis,Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
MST3/STK24 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. In response to apoptotic signals, MST3/STK24 is cleaved by caspase-3 and mediates apoptosis. The biological functions of MST3/STK24 are not well understood.
UniGene ID
Hs.508514
UniProt ID (eCommerce)
Q9Y6E0
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.