human STAT5B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human STAT5B.
shADV-224542
Ad-h-STAT5B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human STAT5B (signal transducer and activator of transcription 5B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
signal transducer and activator of transcription 5B; STAT5; transcription factor STAT5B
Description (eCommerce)
Signal transducer and activator of transcription 5b (STAT5b) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5A mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression [taken from NCBI Entrez Gene (Gene ID: 6777)].
Description (Vector)
STAT5B is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Gene ID
6777
Gene Name (eCommerce)
signal transducer and activator of transcription 5B
Gene Name (Vector)
signal transducer and activator of transcription 5B
Gene Symbol
STAT5B
HGNC ID
HGNC:11367
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2364
ORF Size (bp)
2364 bp
Protein Name (eCommerce)
Signal transducer and activator of transcription 5B
RefSeq ID
NM_012448
RefSeq Synonyms
NM_012448, BC065227, BC020868,
Research Areas
Apoptosis,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,Cell Cycle,Cytokine Signaling,EGFR Signaling,EPO Signaling,FGF Signaling,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leptin Signaling,Leukemia,Metabolism/Metabolic Process,Neurobiology,PDGF Signaling,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,TPO Signaling,Transcription Factor/Regulator,TSLP Signaling,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Signal transducer and activator of transcription 5b (STAT5b) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5A mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression [taken from NCBI Entrez Gene (Gene ID: 6777)].
UniGene ID
Hs.595276
UniProt ID (eCommerce)
P51692
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.