mouse SMARCA2 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-272610
Availability:
3-5 weeks
Name:
Ad-m-SMARCA2-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Smarca2.
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Smarca2
- Gene Name
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
- Gene ID
- 67155
- Gene Synonyms
- 2610209L14Rik; brahma; brm; SNF2alpha; Snf2l2
- ORF Size
- 4734 bp
- RefSeq#
- NM_011416
- Gene Description
- Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
- UniGene ID
- Mm.477499
Related Products
Product | Cat No. |
---|---|
Ad-SMARCA2/SNF2(alpha) | 1470 |
Ad-h-SMARCA2 | ADV-223709 |
Ad-m-SMARCA2 | ADV-272610 |
AAV-h-SMARCA2-shRNA | shAAV-223709 |
AAV-m-SMARCA2-shRNA | shAAV-272610 |
Ad-h-SMARCA2-shRNA | shADV-223709 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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