human STAM shRNA silencing Adenovirus

Name 
Ad-h-STAM-shRNA
Cat No 
shADV-224504
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human STAM.

shADV-224504
Ad-h-STAM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human STAM (signal transducing adaptor molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HSE1 homolog; signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM1; STAM-1
Description (eCommerce)
Signal transducing adapter molecule 1 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. STAM1 may also play a role in T-cell development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q92783].
Description (Vector)
STAM encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
8027
Gene Name (eCommerce)
signal transducing adaptor molecule
Gene Name (Vector)
signal transducing adaptor molecule
Gene Symbol
STAM
HGNC ID
HGNC:11357
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1212
ORF Size (bp)
1212 bp
Protein Name (eCommerce)
Signal transducing adapter molecule 1
RefSeq ID
NM_003473
RefSeq Synonyms
NM_003473, NM_001324289, NM_001324288, NM_001324287, NM_001324286, NM_001324285, NM_001324284, NM_001324283, NM_001324282, BC030586,
Research Areas
Cancer,EGFR Signaling,EGFR Signaling in Cancer,Interleukin Signaling,JAK-STAT Signaling,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,cancer,immunology
Species
human
Target Sentence
Signal transducing adapter molecule 1 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. STAM1 may also play a role in T-cell development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q92783].
UniGene ID
Hs.441498
UniProt ID (eCommerce)
Q92783

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.